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Parents of lost babies and potential of all kinds: come here to share the technicolour, the vividness, the despair, the heart-broken-open, the compassion we learn for others, having been through this mess — and see it reflected back at you, acknowledged and understood.

Thanks to photographer Xin Li and to artist Stephanie Sicore for their respective illustrations and photos.

ttc | pregnancy | birth after loss > "False positive" Lupus Anticoagulant

Hello,

Just wondering if anyone has run into this before with their bloodwork.

I requested a copy of my recent blood work for thrombophilias, my placental pathology and Riyad's autopsy reports. I never had them before or looked at them. I felt silly because looking at the autopsy report obviously upset me, and brought on a new wave of grief yesterday. Not sure why I put myself through that torture, but I guess I just needed to know the doctors were correct in telling me there was nothing abnormal about him at all. Also, according to them, my blood tests were all "normal," but one thing makes me question that. My Lupus Anticoagulant screen says I am negative for it. However, when I look at the testing underneath Lupus, the DRVVT tests, one reads positive. The report then "corrects" it and states this subnote:
"The corrected mixing study pattern is most commonly associated with a Factor(s) deficiency - commonly acquired due to anticoagulant therapy. This suggests that the positive DRVVT confirm is either a false positive or due to a weak Lupus Anticoagulant. Clinical correlation is required."
So, seeing that, wouldn't it make sense for them to test me again, or at least do further testing???? I am done with this OB's office, I guess maybe I can bring up these concerns to my future MFM?

Also, wondering if anyone had this for the placental pathology...it was described as a "mature third trimester placenta with focal intervillous fibrin deposition, placental weight less than 50th percentile gestational age." So an old, small placenta? With "less than 3 cc of adherent blood clot at the edge of the disk which is loosely adherent." Old, small placenta with a blood clot that partially came away.

Sorry, I know none of us here are doctors, I just wanted to know if anyone ran into something similar with a false positive test, or had a similar placental pathology report. And if you did, how did you go forward with this knowledge? Wishing everyone some peace today.
March 10, 2017 | Unregistered CommenterNada
Hi Nada, these hypercoaguability tests often have to be interpreted by a hematologist and be looked at all together as a whole, since sometimes one positive on its own is or isn't enough to point to a diagnosis. If there is any question about the initial results particularly if there were done at the time of delivery or very shortly thereafter, the recommendation is usually to have them repeated 6 or 12 weeks post partum. If they are still positive it may suggest a need for use of blood thinners in your next pregnancy, although a lot of that is based just on expert opinion and not on any good data from clinical trials. It might be a good idea to run this question by your MFM (have you had any preconception counseling?) to see if repeat testing is needed.

Thinking of you. This is all so hard and always triggering to delve back in and think about what happened to our babies. I will always question if there's anything I could have done or known earlier for my first pregnancy even though I know it probably wouldn't have made a difference. I think too what's so hard thinking ahead is that there are so many more problems that are way more common than stillbirth and what happened to our babies. How to overcome all these barriers? But in the end there's not much we are in control of, and all we can do is take care of ourselves, try to hopeful, and honor our babies.
March 11, 2017 | Unregistered CommenterSteph
Hi Steph, thank you for responding to my post. I did have preconception counseling with my MFM but it was before I got these blood results back. I was too eager to wait on the blood test results so I basically just ran there with little to no files sent to her yet. I called her this morning to get her opinion and I guess she is happy with the blood tests she has seen so far, that they are negative, but she has additional bloodwork she wants to order to be on the safe side -- Anticardiolipin antibodies. I THINK this was in response to the false positive I saw. Either way I got some comfort when I spoke to her because it sounds like she's being very diligent and cautious, and actually cares about my results...a vibe I didn't get from my regular OB who is way too laidback for my tastes, even after my son's stillbirth.

It definitely is triggering delving into all of this again. I oddly find it empowering too. The fact that we are doing SOMETHING, moving forward to hopefully guarantee a safer future for any future babies we may have. I constantly go back in time and question and wonder if I could have prevented my son's death...but...I am learning slowly not to blame myself. It's hard, the guilt, the what-ifs, but we only knew what we could know before our babies passed away. We had no real knowledge of stillbirths and that it was an actual risk, because we are led to believe it's such a small percentage that it couldn't possibly happen to us. But now we know, and that was AFTER our tragedies occurred. We can't possibly think we knew or could have known our babies were in distress, when we simply didn't have the knowledge to know. Like you said, we can't control every situation, and this was completely out of our hands.....so the best we can do is take charge of things we CAN control, like our health, research into what happened, and making a preventive care plan with our doctors. And focusing on helping ourselves to heal.......that's a huge one.
March 17, 2017 | Unregistered CommenterNada