ttc | pregnancy | birth after loss > IVF genetic testing advice: day 3 vs day 5 biopsy
I don't have any advice unfortunately. I wish you much "luck" in moving forward. I've never heard of being able to do day 3 testing. I thought you had to go to day 5 because of the need for more cells. We recently had twins from an IVF pregnancy and the only option for testing offered was 5 day (we did not feel we needed to do it yet). Why couldn't they do a fresh cycle with day 5 testing? Does it take too long to get the tests back?
April 21, 2015 |
Carrie
Carrie
my thoughts on day 3 vs day 5 screening.
day three, they will only take one or two cells for the biopsy.
day five, they will be able to take many more and they will most likely be taken from the outer cell mass, which will eventually become the placenta, so they are not removing cells from what will become the baby.
fresh vs. FET-
current lab techniques are much better for freezing and thawing- it used to be that most labs used a slow-freezing method which was hard on the embryos. I believe that most labs now use a flash freezing vitrification, which has almost no ill effects on the embryos.
by doing a FET, your body is more 'in-sync' hormonally.
the only drawback is that you have to wait for the biopsy results.
the fact is that for a long time, fresh transfers were considered great and lots of people got pregnant and had babies. trends in IVF change as the technology advances. the clinic we used has totally changed their protocols toward doing FETs with genetic screening, because the stats are so much better, even and especially for women in their late 30's and early 40's.
you want to make sure you are at the best clinic with the best lab that your money and time can afford. even if it means travelling out of state and spending a little more.
TY, I am very sorry for your losses. we chose to do screening because we had many losses and I was not able to risk transferring an embryo that was destined for a m/c or later loss again. back then, we were not offered fresh transfer options, and honestly, it made sense to me about waiting for the stims to clear out of my system and then wait to sync up with the FET hormones.
I do think that there are some clinics that can offer same-cycle screening for a fresh transfer, but only for day 3 biopsies... my last IVF transfer was in 2010, so I am already way behind on what is current.
day three, they will only take one or two cells for the biopsy.
day five, they will be able to take many more and they will most likely be taken from the outer cell mass, which will eventually become the placenta, so they are not removing cells from what will become the baby.
fresh vs. FET-
current lab techniques are much better for freezing and thawing- it used to be that most labs used a slow-freezing method which was hard on the embryos. I believe that most labs now use a flash freezing vitrification, which has almost no ill effects on the embryos.
by doing a FET, your body is more 'in-sync' hormonally.
the only drawback is that you have to wait for the biopsy results.
the fact is that for a long time, fresh transfers were considered great and lots of people got pregnant and had babies. trends in IVF change as the technology advances. the clinic we used has totally changed their protocols toward doing FETs with genetic screening, because the stats are so much better, even and especially for women in their late 30's and early 40's.
you want to make sure you are at the best clinic with the best lab that your money and time can afford. even if it means travelling out of state and spending a little more.
TY, I am very sorry for your losses. we chose to do screening because we had many losses and I was not able to risk transferring an embryo that was destined for a m/c or later loss again. back then, we were not offered fresh transfer options, and honestly, it made sense to me about waiting for the stims to clear out of my system and then wait to sync up with the FET hormones.
I do think that there are some clinics that can offer same-cycle screening for a fresh transfer, but only for day 3 biopsies... my last IVF transfer was in 2010, so I am already way behind on what is current.
April 22, 2015 |
ss
ss
Thank you for sharing Carrie and sme.
How do you find out which is the best clinic with the nest lab? Is there a web site that puts out those stats or do you have to call around and ask specific questions about each clinic's stats?
How do you find out which is the best clinic with the nest lab? Is there a web site that puts out those stats or do you have to call around and ask specific questions about each clinic's stats?
April 22, 2015 |
TY
TY
a good place to start is the SART site, which allows you to see a clinics stats,
categories, etc. state by state.
http://www.sart.org/find_frm.html
we chose our first clinic really because it was the nearest one to us and our midwife referred all of her 'difficult' cases to them, so we went and liked the people there. I knew nothing about IVF and what to expect. after a few years and being on forums and clicking away online, you start seeing where people are currently having success or failures or whatever... that is totally a subjective thing, getting info online like that, but you can back it up with the SART stats (which are a couple years old by the time they get published).
in the end we travelled across country to CCRM in Denver. at the time, they were having amazing success and were cutting edge. I was approaching 40 so I just went 'all-in' and went there, it was expensive but it seemed like the smartest way to spend our money. that was 5 years ago, and I have no idea what is current in so far as top clinics etc.
categories, etc. state by state.
http://www.sart.org/find_frm.html
we chose our first clinic really because it was the nearest one to us and our midwife referred all of her 'difficult' cases to them, so we went and liked the people there. I knew nothing about IVF and what to expect. after a few years and being on forums and clicking away online, you start seeing where people are currently having success or failures or whatever... that is totally a subjective thing, getting info online like that, but you can back it up with the SART stats (which are a couple years old by the time they get published).
in the end we travelled across country to CCRM in Denver. at the time, they were having amazing success and were cutting edge. I was approaching 40 so I just went 'all-in' and went there, it was expensive but it seemed like the smartest way to spend our money. that was 5 years ago, and I have no idea what is current in so far as top clinics etc.
April 23, 2015 |
ss
ss
Thanks ss. That's all very helpful.
I also came across this site, which might not be a reputable, but it is helpful in that it ranks each clinic based on their success rates and breaks down success rates for each clinic in a easy to read table instead of having to look up each clinic one by one and finding out their success rates:
http://fertilitysuccessrates.com/report/United-States/women-under-35/data.html
I also came across this site, which might not be a reputable, but it is helpful in that it ranks each clinic based on their success rates and breaks down success rates for each clinic in a easy to read table instead of having to look up each clinic one by one and finding out their success rates:
http://fertilitysuccessrates.com/report/United-States/women-under-35/data.html
April 24, 2015 |
TY
TY
As the subject suggests, I am looking for IVF genetic testing advice, specifically doing a day 3 biopsy with a fresh cycle versus a day 5 biopsy with a frozen/thaw cycle. Both have their advantages, but the day 3 might be more of a draw back? I am in my late 30's and am newly embarking on IVF, especially after having a recent miscarriage after a neonatal loss a year ago. Any experience, thoughts, or musings are very welcomed.